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VEGFA Rabbit pAb (bs-0279R)  
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產(chǎn)品編號(hào) bs-0279R
英文名稱 VEGFA Rabbit pAb
中文名稱 血管內(nèi)皮生長(zhǎng)因子抗體
別    名 Vascuoar endothelial growth factor A; VEGF A; vascular endothelial growth factor A isoform 2 precursor; MGC70609; MVCD1; VEGF; VPF; VEGFA_HUMAN; VEGF-A; Vascular permeability factor(VPF);  
Specific References  (40)     |     bs-0279R has been referenced in 40 publications.
[IF=16.744] Xiaoyu Ma. et al. Multifunctional injectable hydrogel promotes functional recovery after stroke by modulating microglial polarization, angiogenesis and neuroplasticity. CHEM ENG J. 2023 May;464:142520  IF ;  Mouse.  
[IF=10.383] Peiyang Gu. et al. Tailorable 3DP Flexible Scaffolds with Porosification of Filaments Facilitate Cell Ingrowth and Biomineralized Deposition. ACS APPL MATER INTER. 2022;XXXX(XXX):XXX-XXX  WB ;  Mouse.  
[IF=7.786] Shiou-Ling Lu. et al. VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes | mBio. MBIO. 2022 Jul;:  WB ;  Escherichia coli.  
[IF=6.78] Cho-Won Kim. et al. The role of KiSS1 gene on the growth and migration of prostate cancer and the underlying molecular mechanisms. LIFE SCI. 2022 Sep;:121009  IHC ;  Mouse.  
[IF=6.208] Feng Zhao. et al. Mechanism Repositioning Based on Integrative Pharmacology: Anti-Inflammatory Effect of Safflower in Myocardial Ischemia–Reperfusion Injury. INT J MOL SCI. 2023 Jan;24(6):5313  WB ;  Mouse.  
[IF=6.064] Shimaa Abdelsattar. et al. The Potential Utility of Circulating Oncofetal H19 Derived miR-675 Expression versus Tissue lncRNA-H19 Expression in Diagnosis and Prognosis of HCC in Egyptian Patients. BIOMOLECULES. 2023 Jan;13(1):3  IHC ;  Human.  
[IF=5.646] Ye T et al. MicroRNA-7 as a potential therapeutic target for aberrant NF-κB-driven distant metastasis of gastric cancer. J Exp Clin?Cancer?Res.?2019 Feb 6;38(1):55.  FCM&IHC ;  Mouse&Human.  
[IF=5.572] Siddharth J. Modi. et al. Discovery of VEGFR-2 inhibitors exerting significant anticancer activity against CD44+ and CD133+ cancer stem cells (CSCs): Reversal of TGF-β induced epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma. Eur J Med Chem. 2020 Dec;207:112851  
[IF=5.256] Wang J et al. A Novel RNA Aptamer-modified Riboswitch as Chemical sensor. Analytica Chimica Acta. (2019).  Other ;  
[IF=5.19] Zhu, Huaisen. et al. Ginsenoside Rg1 regulates thiram-induced chondrocytes’ apoptosis and angiogenesis in broiler chickens. ENVIRON SCI POLLUT R. 2022 Dec;:1-15  WB ;  Chicken.  
[IF=4.938] Chen et al. Circulating fibrocyte mobilization in negative pressure wound therapy. (2017) J.Cell.Mol.Me. 21:1513-1522  WB ;  Rat.  
[IF=4.755] Bae Ju-Eun. et al. Effects of erythropoietin on osteoblast in the tooth extraction socket in mice periodontitis model. FRONT PHYSIOL. 2022 Oct;0:2117  IHC ;  Mouse.  
[IF=4.26] Bi et al. Peripheral serotonin regulates postoperative intra-abdominal adhesion formation in mice. (2017) Sci.Rep. 7:10001  IHC ;  Mouse.  
[IF=3.923] Yang Y et al. Inhibition of microRNA‐129‐5p expression ameliorates ultraviolet ray‐induced corneal epithelial cell injury via upregulation of EGFR. (2018) J Cell Physiol.  WB ;  Mouse.  
[IF=3.89] Ryzhov, Sergey, et al. "Role of a2b adenosine receptors in regulation of paracrine functions of stem cell antigen 1-positive cardiac stromal cells." Journal of Pharmacology and Experimental Therapeutics 341.3 (2012): 764-774.  Mouse.  
[IF=3.719] Tingting Guo. et al. Bone regeneration of mouse critical-sized calvarial defects with human mesenchymal stem cell sheets co-expressing BMP2 and VEGF. J DENT SCI. 2022 Jul;:  WB ;  Human.  
[IF=3.571] Mei F et al. Collagen peptides isolated from Salmon salar and Tilapia nilotica skin accelerate wound healing by altering cutaneous microbiome colonization via up-regulated NOD2 and BD14. Agric. Food Chem. 2020, 68, 6, 1621-1633.  IHC-P ;  Rat.  
[IF=3.423] Qi Rao. et al. Alcohol extracts from Anemone?flaccida Fr. Schmidt treat rheumatoid arthritis via inhibition of synovial hyperplasia and angiogenesis. MOL MED REP. 2023 Apr;27(4):1-12  IHC,WB ;  Rat,Human.  
[IF=3.41] Qi, Yuanyuan, et al. "Inhaled NO contributes to lung repair in piglets with acute respiratory distress syndrome via increasing circulating endothelial progenitor cells." PloS one 7.3 (2012): e33859.  WB ;  Pig.  
[IF=3.375] Zheng Chen. et al. Glycine attenuates cerebrovascular remodeling via glycine receptor alpha 2 and vascular endothelial growth factor receptor 2 after stroke. Am J Transl Res. 2020; 12(10): 6895–6907  IF,IHC ;  Rat.  
[IF=3.361] Varghese S et al. Immunostimulatory?plant?polysaccharides?impede?cancer?progression?and?metastasis?by?avoiding?off-target?effects. Int Immunopharmacol. 2019 May 21;73:280-292.  WB ;  Human.  
[IF=3.332] Sun Y et al. The function of Piezo1 in colon cancer metastasis and its potential regulatory mechanism. J Cancer Res Clin Oncol. 2020 May;146(5):1139-1152.  IHC,WB ;  human.  
[IF=3.17] Li, Junqin, et al. "Fatty Acid Synthase Mediates the Epithelial-Mesenchymal Transition of Breast Cancer Cells." International Journal of Biological Sciences 10.2 (2014): 171-180.  WB ;  Human.  
[IF=3.14] Varghese, Sheeja, et al. "The inhibitory effect of anti-tumor polysaccharide from Punica granatum on metastasis." International Journal of Biological Macromolecules (2017).  WB ;  Human.  
[IF=2.842] Guangrui Chai. et al. NLRP3 Blockade Suppresses Pro-Inflammatory and Pro-Angiogenic Cytokine Secretion in Diabetic Retinopathy. Diabet Metab Synd Ob. 2020; 13: 3047–3058  WB ;  Human.  
[IF=2.72] Jiebin Li. et al. Targeted Temperature Management Suppresses Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Expression in a Pig Model of Cardiac Arrest. 2021 Jan 05  WB ;  Pig.  
[IF=2.63] Jin Yang. et al. Protective Effect and Potential Mechanism of the Traditional Chinese Medicine Shaoyao-Gancao Decoction on Ethanol-Induced Gastric Ulcers in Rats. EVID-BASED COMPL ALT. 2022;2022:3069089  IHC ;  Rat.  
[IF=2.59] Zeng, K.-W., et al., Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis. Eur J Pharmacol (2013)  Mouse.  
[IF=2.467] Zheng W et al. An injectable thermosensitive hydrogel for sustained release of apelin-13 to enhance flap survival in rat random skin flap. J Mater Sci Mater Med. 2019 Sep 9;30(9):106.  IHC&WB ;  Rat.  
[IF=2.219] Fernandez-Bueno I et al. Reliability and reproducibility of a rodent model of choroidal neovascularization based on the subretinal injection of polyethylene glycol.Mol Vis. 2019 Mar 18;25:194-203.  IHC-P ;  Mouse.  
研究領(lǐng)域 腫瘤  心血管  生長(zhǎng)因子和激素  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat
產(chǎn)品應(yīng)用 WB=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 24 kDa
檢測(cè)分子量
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VEGF: 27-120/232 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Also, alternative translation initiation from non-AUG (CUG) and AUG start sites in some transcript variants, give rise to additional isoforms. [provided by RefSeq].

Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.

Subunit:
Homodimer; disulfide-linked. Also found as heterodimer with PGF.

Subcellular Location:
Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.

Tissue Specificity:
Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed.

DISEASE:
Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

Similarity:
Belongs to the PDGF/VEGF growth factor family.

SWISS:
P15692

Gene ID:
7422

Database links:

Entrez Gene: 7422 Human

Entrez Gene: 22339 Mouse

Entrez Gene: 83785 Rat

Omim: 192240 Human

SwissProt: P15692 Human

SwissProt: Q00731 Mouse

SwissProt: P16612 Rat

Unigene: 73793 Human

Unigene: 282184 Mouse

Unigene: 1923 Rat





生長(zhǎng)因子和激素(Growth Factor and Hormones) 血管內(nèi)皮細(xì)胞生長(zhǎng)因子(VEGF)是一種特異作用于血管內(nèi)皮細(xì)胞的多功能細(xì)胞因子,它能引起血管通透性增加,引起細(xì)胞外基質(zhì)成分改變,誘導(dǎo)血管形成.在炎癥、創(chuàng)傷愈合、心臟缺血、動(dòng)脈粥樣硬化、糖尿病性視網(wǎng)膜病變及腫瘤形成等與血管生成和病變有關(guān)的諸多病理過程中起重要作用.
VEGF與血管生成有關(guān),從而也與腫瘤生長(zhǎng)也有很大關(guān)系,近年來受到很多關(guān)注.
產(chǎn)品圖片
Sample: Kidney(Mouse) Lysate at 30 ug Primary: Anti-VEGF (bs-0279R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 25 kD
Sample: Heart(Mouse) Lysate at 30 ug Primary: Anti-VEGF (bs-0279R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 25 kD
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