| 產(chǎn)品編號(hào) | bs-2420R |
| 英文名稱 | NCR2 Rabbit pAb |
| 中文名稱 | 細(xì)胞毒性受體NK-p44抗體 |
| 別 名 | Natural killer cell p44-related protein; CD336; CD336 antigen; LY95; Lymphocyte antigen 95 homolog; Lymphocyte antigen 95(activating NK receptor; NK p44); Natural cytotoxicity triggering receptor 2; Natural killer cell p44-related protein; NK cell activat |
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Specific References (2) | bs-2420R has been referenced in 2 publications.
[IF=15.304] Yao Lei. et al. Phytochemical natural killer cells reprogram tumor microenvironment for potent immunotherapy of solid tumors. BIOMATERIALS. 2022 Jun;:121635 WB, IF, FC ; Mouse.
[IF=8.713] Rimma Laufer Britva. et al. Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata. ELIFE. 2023 Mar ICC ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞膜受體 自然殺傷細(xì)胞 t-淋巴細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 28 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD336: 201-276/276 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
NCR2 (NKp44) is a member of the natural cytotoxicity receptor (NCR) family that is expressed on activated human NK cells. NCR2 displays a single extracellular Ig-like V domain and a transmembrane portion containing the charged residue (Lysine), likely involved in the association with KARAP/DAP12 molecules. Gene coding for NCR2 maps on human chromosome 6p21.1 Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Subunit: Interacts with TYROBP/DAP12. Subcellular Location: Cell membrane; Single-pass type I membrane protein (Potential). Tissue Specificity: Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells. Similarity: Belongs to the natural cytotoxicity receptor (NCR) family. Contains 1 Ig-like (immunoglobulin-like) domain. SWISS: O95944 Gene ID: 9436 Database links: Entrez Gene: 9436 Human GenBank: NM_004828 Human Omim: 604531 Human SwissProt: O95944 Human Unigene: 194721 Human 細(xì)胞毒性受體家族（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表達(dá)于所有靜止和活化的NK細(xì)胞，而NKp44則選擇性的表達(dá)于活化的NK細(xì)胞。靶細(xì)胞上的配體分子與NCRs的結(jié)合（交聯(lián)）引發(fā)NK細(xì)胞的活化導(dǎo)致靶細(xì)胞的裂解和大量細(xì)胞因子的產(chǎn)生?，F(xiàn)已確認(rèn)NKp46和NKp44可以識(shí)別病毒上的配體分子紅血球凝聚素，而NKp46則能識(shí)別腫瘤細(xì)胞上的乙酰硫酸多聚糖。 |
