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NEGR1 Rabbit pAb (bs-11095R)  
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50ul/1180.00元
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200ul/2800.00元
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產(chǎn)品編號(hào) bs-11095R
英文名稱 NEGR1 Rabbit pAb
中文名稱 神經(jīng)生長(zhǎng)調(diào)節(jié)蛋白1抗體
別    名 A kindred of IgLON; DMML2433; IgLON family member 4; IGLON4; KILON; Neuronal growth regulator 1; Neurotractin; Ntra; PRO4993; UNQ2433; NEGR1_HUMAN.  
Specific References  (1)     |     bs-11095R has been referenced in 1 publications.
[IF=6.064] Haofuzi Zhang. et al. Identification of a Fibroblast-Related Prognostic Model in Glioma Based on Bioinformatics Methods. BIOMOLECULES. 2022 Nov;12(11):1598  IHC ;  Human.  
研究領(lǐng)域 發(fā)育生物學(xué)  神經(jīng)生物學(xué)  細(xì)胞粘附分子  細(xì)胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 31 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NEGR1: 38-130/354 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 NEGR1 is a 354 amino acid protein belonging to the IgLON family and immunoglobulin superfamily. NEGR1 may play a role in cell adhesion and regenerative axon sprouting in the mammalian brain and is highly expressed in adult hippocampus, cerebrum and brainstem, with much lower levels found in cerebellum. Localizing to the cell membrane at the glycosylphosphatidylinositol anchor (GPI) anchor, NEGR1 contains three Ig-like C2-type (immunoglobulin-like) domains. NEGR1 is encoded by a gene that maps to human chromosome 1p31.1, and is one of several loci associated with body mass index (BMI), possibly contributing to the development of obesity.

Function:
NEGR1 may be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor

Similarity:
Belongs to the immunoglobulin superfamily. IgLON family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
Q7Z3B1

Gene ID:
257194

Database links:

Entrez Gene: 257194 Human

Entrez Gene: 320840 Mouse

Entrez Gene: 59318 Rat

Omim: 613173 Human

SwissProt: Q7Z3B1 Human

SwissProt: D3Z4T6 Mouse

SwissProt: D4A2V0 Rat



產(chǎn)品圖片
Sample: Muscle (Mouse) Lysate at 40 ug Primary: Anti-NEGR1 (bs-11095R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 37 kD
Sample: Brain (Mouse) Lysate at 40 ug Primary: Anti-NEGR1 (bs-11095R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 37 kD
Sample: Cerebellum (Mouse) Lysate at 40 ug Primary: Anti-NEGR1 (bs-11095R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 37 kD
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