亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
高清国产激情视频在线观看,久久天天躁狠狠躁夜夜躁2014,一级毛片免费在线播放
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
phospho-DNA-PKcs (Ser3191) Rabbit pAb (bs-10994R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-10994R
英文名稱 phospho-DNA-PKcs (Ser3191) Rabbit pAb
中文名稱 磷酸化DNA依賴性蛋白激酶抗體
別    名 DNA PK(phospho S3191); p-DNA PK(phospho S3191); PRKDC(phospho T3191); PRKDC_HUMAN; DNA-dependent protein kinase catalytic subunit; EC:2.7.11.1; PRKDC; HYRC; HYRC1; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460;  
產(chǎn)品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  免疫學  染色質和核信號  轉錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat (predicted: Human,Pig,Dog,Horse)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 454 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human DNA PKcs around the phosphorylation site of Ser3191: FL(p-S)KI 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]

Function:
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D.

Subunit:
DNA-PK is a heterotrimer of PRKDC and the Ku p70-p86 (XRCC6-XRCC5) dimer. Formation of this complex may be promoted by interaction with ILF3. Associates with the DNA-bound Ku heterodimer, but it can also bind to and be activated by free DNA. Interacts with DNA-PKcs-interacting protein (KIP) with the region upstream the kinase domain. PRKDC alone also interacts with and phosphorylates DCLRE1C, thereby activating the latent endonuclease activity of this protein. Interacts with C1D. Interacts with TTI1 and TELO2.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. Autophosphorylated on Thr-2609, Thr-2638 and Thr-2647. Thr-2609 is a DNA damage-inducible phosphorylation site (inducible with ionizing radiation, IR). Autophosphorylation induces a conformational change that leads to remodeling of the DNA-PK complex, requisite for efficient end processing and DNA repair.
S-nitrosylated by GAPDH.

Similarity:
Belongs to the PI3/PI4-kinase family.
Contains 1 FAT domain.
Contains 1 FATC domain.
Contains 2 HEAT repeats.
Contains 1 PI3K/PI4K domain.
Contains 3 TPR repeats

SWISS:
P78527

Gene ID:
5591

Database links:

Entrez Gene: 5591 Human

Entrez Gene: 19090 Mouse

Entrez Gene: 360748 Rat

Omim: 600899 Human

SwissProt: P78527 Human

SwissProt: P97313 Mouse

Unigene: 491682 Human

Unigene: 71 Mouse



版權所有 2004-2026 m.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
欧美精品九九99久久在免费线 | 欧美日韩1卡2卡3卡免费高清中文精品字幕 | 亚洲成a人v欧美综合天堂下载 | 最新亚洲中文字幕一区在线 | 欧美乱色伦图片区小说 | 国产一区二区三区视频 | 免费无遮挡无码视频在线观看洗澡 | 亚洲中文字幕在线第六区 | 韩日AV无码片一区二区三区 | 人妻体内射精一区二区 | 人妻仑乱少妇88MAV | WWW成人国产高清内射 | 日韩一区二区三区四区区区 | 校园久久综合激情四射伊人丁香 | 成人片毛片AAA片免费 | 欧美性videos高清精品 | 一级做a爰片久久毛片毛片 色哟哟国产精品一区二区真心好看 | 亚洲精品午夜久久久久久久久 | 另类内射国产在线 | 最近中文字幕大全在线电影视频 | 精品人妻大屁股白浆久久 | 最近2019免费中文第一页 | 亚洲欧美国产成人综合不卡 | 女人被男人吃奶到高潮 | 欧美精品免费观看二区 | 91精品久久久久久中文字幕 | 水蜜桃亚洲一二三四在线 | 免费成人在线观看 | 最近中文字幕MV免费高清动漫 | 成年必看视频在线观看 | 为您提供久久久久国产精品 | 亚洲AV午夜福利无码精品一区 | 国产AV电影区二区三区曰曰骚网 | 亚洲欧美日韩性爱一区精品 | 国产黄片高清无码在线观看 | 欧美亚洲另类丝袜自拍动漫 | 女人赤裸裸正面下身照片 | 国产又黄又爽胸又大免费视频 | 一级毛片丰满**出奶水 | 精品人妻无码一区二区三区在线 | 天堂8中文在线最新版官网 91日本在线视频 |