| 產(chǎn)品編號(hào) |
bs-41432P |
| 英文名稱 |
Recombinant SARS-Cov-2 Papain-Like Protease, His
|
| 中文名稱 |
重組SARS-CoV-2 (2019-nCoV) Papain-Like Protease |
| 別 名 |
Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a; Recombinant SARS-Cov-2 Papain-Like Protease, His 新冠病毒PLpro; 新冠PLpro; SARS-CoV-2 PLpro; |
| 克 隆 號(hào) |
|
| 理論分子量 |
35.8 kDa |
| 檢測(cè)分子量 |
26 |
| 性 狀 |
Liquid |
| 濃 度 |
＞0.5 mg/ml |
| 物 種 |
SARS-Cov-2 |
| 序 列 |
1564-1880/7096 |
| 純 度 |
>90% as determined by SDS-PAGE |
| 純化方法 |
AC |
| 內(nèi)毒素 |
Not analyzed |
| 表達(dá)系統(tǒng) |
E.coli |
| 活性 |
Not tested |
| 標(biāo)簽 |
His |
| 保存條件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.
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