亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
亚洲日韩精品一区二区二,亚洲免费在线播放,在线视频一区二区三区四区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-eIF4G (ser1185)/Cy5.5 Conjugated antibody (bs-4003R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4003R-Cy5.5
英文名稱 Rabbit Anti-phospho-eIF4G (ser1185)/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的磷酸化真核翻譯起始因子4G抗體
別    名 eIF4G (phospho-Ser1185); eIF4G (phospho-S1185); p-eIF4G (Ser1185); p-eIF4G (S1185); eIF 4 gamma 1; eIF 4G 1; eIF 4G1; EIF4 gamma; EIF4F; EIF4G; EIF4GI; Eukaryotic translation initiation factor 4 gamma 1; p220; DKFZp686A1451; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; EIF4G-I; IF4G1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 免疫學  染色質和核信號  信號轉導  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 176kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human eIF4G around the phosphorylation site of ser1185
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Summary: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq].

Function:
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.

Subunit:
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis. Interacts with RBM4.

Post-translational modifications:
Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.
Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.

DISEASE:
Defects in EIF4G1 are the cause of Parkinson disease type 18 (PARK18) [MIM:614251]. An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.

Similarity:
Belongs to the eIF4G family.
Contains 1 MI domain.
Contains 1 MIF4G domain.
Contains 1 W2 domain.

Database links:

Entrez Gene: 1981 Human

Entrez Gene: 208643 Mouse

Entrez Gene: 287986 Rat

Omim: 600495 Human

SwissProt: Q04637 Human

SwissProt: Q6NZJ6 Mouse

SwissProt: Q4G001 Rat

Unigene: 433750 Human

Unigene: 260256 Mouse

Unigene: 101803 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 m.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
晓雪老师我要进你里面好爽 | 女人被弄到高潮的免费视频 | 米奇奇米777第四色 国产精品免费大片 | 粗大猛烈进出高潮视频大全 | 精品无码久久久久久久久 | 亚洲已满18点击进入在线观看 | 亚洲综合色区另类aV无码 | 推油少妇久久99久久99久久 | 七姐妹在线观看免费播放国语 | 神马免费午夜福利剧场 | 久久久久久亚洲av无码专区 | 91久久综合精品国产丝袜长腿 | 强行无套内大学生初次 | 国产91视频观看 | 校园久久综合激情四射伊人丁香 | 成年人在线免费网站 | 国产超碰人人模人人爽人人添 | 亚洲91无码精品一区在线播放 | 亚洲欧美日韩一本无线码专区 | 为您提供久久久久国产精品 | 一本精品99久久精品66不卡婷婷 | 欧美写真视频一区 | 青春草视频在线观看 | 亚洲天天在线日亚洲洲精 | 亚洲人成日韩中文字幕不卡 | 国产精品一区二区免费 | 国产性自爱拍偷在在线播放 | 两根硕大一起挤进小紧H共妻 | 97在线精品视频免费 | 国产精品99无码一区二区 | 亚洲午夜在线播放 | 欧美精品18videose×性欧美 | 国产一级高清A片免费播 | 囯产精品一区二区三区线 | 女自慰喷潮久久久.www | 国产精品成人久久久久无码 | 扒开腿挺进湿润的花苞HD视频 | 欧美白嫩精品一区二区 | 国产又大又黑又粗免费视频 | 亚洲熟女乱色一区二区三区 | 污视频在线免费观看网站 |