| 產(chǎn)品編號 | bs-5765R-BF488 |
| 英文名稱 | Rabbit Anti-LANCL2/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的G蛋白偶聯(lián)受體69B |
| 別 名 | G protein coupled receptor 69B; LanC (bacterial lantibiotic synthetase component C) like 2; TASP; Testis specific adriamycin sensitivity protein; LANC2_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 染色質(zhì)和核信號 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 51kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LANCL2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: LANCL2 belongs to the LanC like protein family. It is expressed in the brain and testis. LANCL2 is a bystander gene coamplified and overexpressed with epidermal growth factor receptor (EGFR) in 20% of all glioblastomas. Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin). Function: Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Subunit: Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association. Subcellular Location: Nucleus. Cytoplasm. Cell membrane. Note=Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo. Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin). Tissue Specificity: Expressed in brain and testis. Post-translational modifications: Myristoylated. Essential for membrane association. Similarity: Belongs to the LanC-like protein family. Database links: UniProtKB/Swiss-Prot: Q9NS86.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
