亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产精品乱码久久久久久,一本无码aⅴ久久久国产 ,成年必看视频在线观看
Rabbit Anti-Sumo 2/RBITC Conjugated antibody (bs-15494R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-15494R-RBITC
英文名稱 Rabbit Anti-Sumo 2/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的泛素樣蛋白Sumo2抗體
別    名 Small ubiquitin-related modifier 2; SUMO-2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3A; Smt3A; SUMO2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 10.9kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sumo 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease

Function:
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

Subunit:
Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains).

Subcellular Location:
Nucleus. Nucleus, PML body.

Tissue Specificity:
Broadly expressed.

Post-translational modifications:
Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
Cleavage of precursor form by SENP1 or SENP2 is necessary for function.

Similarity:
Belongs to the ubiquitin family. SUMO subfamily.
Contains 1 ubiquitin-like domain.

Database links:

Entrez Gene: 6612 Human

Entrez Gene: 6613 Human

Entrez Gene: 170930 Mouse

Entrez Gene: 20610 Mouse

Entrez Gene: 397044 Pig

Entrez Gene: 499417 Rat

Entrez Gene: 690244 Rat

Omim: 602231 Human

Omim: 603042 Human

SwissProt: P61955 Cow

SwissProt: P55854 Human

SwissProt: P61956 Human

SwissProt: P61957 Mouse

SwissProt: Q9Z172 Mouse

SwissProt: P61958 Pig

SwissProt: P61959 Rat

SwissProt: Q5XIF4 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 m.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产精品久久久久三级无码 | 0国产一级广片内射视频播放麻豆 | 国产精品一区二区熟女不卡 | 穿着白丝被强行侵犯漫画 | 国产又湿又黄又硬又刺激视频 | 永久免费A片在线观看无码 免费一级A片毛毛片在线播放99 | 一本一道久久a久久综合蜜桃 | 久久线看在观草草青青脱裤 | 娇妻在客厅被朋友玩得呻吟漫画 | 欧美一区二区三区红桃小说 | 一本视频精品中文字幕 | 一个人免费观看视频www | 性生生活色欲片性按摩 | 亚洲精品在线免费 | 黄色一级视频免费看 | 亚洲免费在线播放 | 亚洲AV一宅男色影视 | 国产精品天天影视久久综合网 | 伊人一本到本勒蕉在线 | 国产91在线高潮白浆在线观看 | 精品精品国产三级A∨在线 **色毛片免费观看 色欲日本人妻久久久久久综合 | 国产偷窥熟女精品视频大全 | 国产偷窥盗摄一区二区 | 婷婷射精AV这里只有精品 | 久久久橹橹橹久久久久高清 | 欧美一级久久久久久久久大 | 亚洲最大日夜无码中文字幕 | 免费被黄动漫网站在线无网观看 | 永久免费毛片在线播放 | 国产亚洲精品精品精品 | 精品一区二区三区四区五区六区 | 少妇爆乳无码av无码专区在 | 无码中字出轨中文人妻中文中 | 美女国产毛片A区内射 | 18禁美女裸体网站免费扒内衣 | 天天色天天干天天 | 在线日韩制服中文字幕视频 | 99国产这里有精品视频 | 欧美成人精品第一区二区三区 | 日韩国产自产拍av在线 | 国产成+人+综合+欧美亚洲 |