亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
免费永久观看美女视频网站网址,国产亚洲欧美成人久久片
Rabbit Anti-phospho-KMT6 (Ser21)/FITC Conjugated antibody (bs-10495R-FITC)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-10495R-FITC
英文名稱 Rabbit Anti-phospho-KMT6 (Ser21)/FITC Conjugated antibody
中文名稱 FITC標(biāo)記的磷酸化抑癌蛋白EZH2抗體
別    名 KMT6 / EZH2 (phospho S21); KMT6 / EZH2 (phospho S21); KMT6/EZH2 (phospho Ser21); p-KMT6/EZH2 (Ser21); p-KMT6/EZH2 (S21); Enhancer of zeste homolog 2; Enx1h; MGC9169; Enhancer of zeste 2; ENX-1; ENX 1; ENX1; EZH1; EZH2; EZH 2; EZH2_HUMAN; Histone-lysine N-methyltransferase EZH2; KMT6A; Lysine N-methyltransferase 6; Enhancer of zeste homolog 2 (Drosophila); Enhancer of zeste, Drosophila, homolog 2; KMT 6; KMT6; KMT6A; WVS2.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 甲基化抗體 
研究領(lǐng)域 免疫學(xué)  微生物學(xué)  b-淋巴細(xì)胞  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Xenopus laevis, Zebrafish,)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human KMT6/EZH2 around the phosphorylation site of Ser21
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011].

Function:
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4.

Subunit:
Binds ATRX via the SET domain (Probable). Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with HDAC1 and HDAC2. Interacts with PRAME.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in many tissues. Overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis.

Post-translational modifications:
Phosphorylated by AKT1. Phosphorylation by AKT1 reduces methyltransferase activity. Phosphorylation at Thr-345 by CDK1 and CDK2 promotes maintenance of H3K27me3 levels at EZH2-target loci, thus leading to epigenetic gene silencing.
Sumoylated.

Similarity:
Belongs to the histone-lysine methyltransferase family. EZ subfamily.
Contains 1 CXC domain.
Contains 1 SET domain.

Database links:

Entrez Gene: 2146 Human

Entrez Gene: 14056 Mouse

Entrez Gene: 100381148 Xenopus laevis

Entrez Gene: 399174 Xenopus laevis

Entrez Gene: 768133 Zebrafish

Omim: 601573 Human

SwissProt: Q15910 Human

SwissProt: Q61188 Mouse

SwissProt: Q4V863 Xenopus laevis

SwissProt: Q98SM3 Xenopus laevis

SwissProt: Q08BS4 Zebrafish

Unigene: 444082 Human

Unigene: 246688 Mouse

Unigene: 19136 Xenopus laevis

Unigene: 47646 Xenopus laevis

Unigene: 76424 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 m.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产日韩精品一区二区在线观看 | 波多野结衣高清无碼中文字幕 | 久久久精品无码一二三区 | 成年人在线免费网站 | 无码AV天堂亚洲内射夫妻 | 国产va免费精品高清在线 | 国产美女视频免费观看的网站 | 白丝校花 扒腿自慰网站 | 国产99视频精品免费视亚洲一级Av无码毛片久久精品 | 最近中文字幕在线中文视频 | 欧洲吸奶大片在线看 | 人妻少妇久久中文字幕app | 伊人精品视频直播 | 午夜不卡久久精品无码免费 | 精品国产乱码久久久久久蜜桃网站 | 曰本a级毛片无卡免费视频 自拍偷区亚洲综合第一页欧18 | 特级做a爰片毛片免费看 | 国产欧美一区二区三区不卡 | 综合精品欧美日韩在线观看 | 国产又粗又猛又爽又黄的视频 | 国产精品爱啪在线播放 | 尤物久久99热国产综合 | 中文天堂网在线最新版 | 欧美手机手机在线视频一区 | 中文文字幕文字幕亚洲色 | 黄色网站在线观看视频 | 牛牛影视午夜免费福利 | 欧美成人免费高清二区三区 | 色综合久久88色综合天天 | 国产精品第100页 | 亚洲乱码国产乱码精品精乡村 | 欧美日韩成人VA精品一区二区三区不卡 | 欧美日韩激情在线一区二区 | 无码AV大香线蕉伊人久久九色 | 午夜夫妻试看120国产 | 免费久久99精品国产自在现 | 麻豆精品人妻一区二区三区蜜桃 | 漂亮人妻被强中文字幕 | 国产亚洲第一伦理第一区 | 久久狠狠亚洲综合色成人18免费网站 | 好吊妞无码中文字幕在线视频 |